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Dimethyl adipate (DMA; chemical formula: C8H14O4), also known as dimethyl hexanedioate or adipic acid dimethyl ester, is a colorless, transparent liquid with a melting point of 8°C and boiling points of 109–110°C at 14 mmHg and 228.7°C at 760 mmHg. It is insoluble in water but soluble in alcohols and ethers. Classified as a low-toxicity substance, it is primarily used in industry as a synthetic intermediate and as a raw material for pharmaceuticals and fragrances, as well as a plasticizer and a high-boiling solvent.

Basic Information
Chinese Name: Dimethyl Adipate
English name: Dimethyl adipate (DMA)
Chinese aliases: Dimethyl adipate; Dimethyl hexanedioate
English aliases: Dimethyl hexanedioate; Dimethyl adipate (adipic acid dimethyl ester); DBE-6 dibasic ester; Adipic acid dimethyl ester; Hexanedioic acid dimethyl ester; 2,4-Dichloro-5-aminosulfomylbenzoic acid; DMA; Dimethyl Adipate (DMA)
CAS RN: 627-93-0
EINECS: 211-020-6
Beilstein: 1707443
Physical and chemical properties:
Appearance: Colorless, transparent liquid
Density: 1.063 g/cm³
Melting point: 8°C
Boiling point: 109–110°C (14 mmHg)
Refractive index: 1.427–1.429
Flash point 107°C
Solubility: Soluble in alcohols and ethers; insoluble in water.
Stability: Under acid or base catalysis, it can undergo hydrolysis, alcoholysis, and ammonolysis reactions.
Toxicity: Low toxicity; LD50 (rats, oral) = 1800 mg/kg.
Uses
It can be used as a raw material for synthetic intermediates, pharmaceuticals, and fragrances, as well as a plasticizer and a high-boiling solvent.
It is also the main component of dimethyl nylon acid.
It can also serve as a feedstock for the hydrogenation production of 1,6-hexanediol.
It can also be used as a gas chromatography reference material.